Clinical Studies of Chronic Fatigue

(These are clinical studies topically related to our research here. We prefer to base our nutritional products on clinical studies more than testimonies as we believe science will back up real natural answers.

Some studies are listed at the end of particular articles. More can be found under the general topics of Monolaurin, Biofilm Enzymes, Essential Oils, etc.). Many experts think CFS may have several causes. However, Lyme disease and Epstein Barr are the two biggest, followed by heavy metal toxins and several other suspects. These references show the broad protection and defense monolaurin offers.

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Monolaurin …was tested for in vitro virucidal activity against 14 human RNA and DNA enveloped viruses (including Epstein Barr) in cell culture. At concentrations of 1% additive in the reaction mixture for 1 h at 23°C, all viruses were reduced in infectivity by >99.9%. Monolaurin was the most effective virucidal agent in that it removed all measurable infectivity from all of the viruses tested. The compounds acted similarly on all the viruses and reduced infectivity by disintegrating the virus envelope. http://onlinelibrary.wiley.com/doi/10.1111/j.1745-4565.1982.tb00429.x/abstract

Ascherio A., Munger K.L., Lenette E.T., Spiegelman D., Hernan M.A., Olek M.J., Hankinson S.E., and Hunter, D.J. “Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study,” JAMA 286(24:3127-9, Dec. 26th, 2001, and the study, Simmons A. “Herpes virus and multiple sclerosis,” Herpes 8(3):60-3, Nov. 2001.

Andersson M, Bagby JR, Dyrehag LE, Gottfries CG Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome. Eur J Pain. 1998;2:133–42. [PubMed]

Ballow M, Seeley J, Purtilo DT, St. Onge S, Sakamoto K, Rickles FR Familial chronic mononucleosis. Ann Intern Med. 1982;97:821–5.

Behan PO, Behan WM, Horrobin D Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990;82:209–16. [PubMed]

Camus F, Henzel D, Janowski M, Raguin G, Leport C, Vilde JL Unexplained fever and chronic fatigue: abnormal circadian temperature pattern. Eur J Med. 1992;1:30–6.

Friedberg F, Jason LA Understanding chronic fatigue syndrome: an empirical guide to assessment and treatment. Washington DC: American Psychological Association. 1998.

Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121:953–9.

Jones JF, Ray CG, Minnich LL, Hicks MJ, Kibler R, Lucas DO Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med. 1985;102:1–7.

Schluederberg A, Straus SE, Peterson P, et al NIH conference. Chronic fatigue syndrome research. Definition and medical outcome assessment. Ann Intern Med. 1992;117:325–31.

Sharpe MC, Archard LC, Banatvala JE, et al A report–chronic fatigue syndrome: guidelines for research. J R Soc Med. 1991;84:118–21.

Swanink CM, Vercoulen JH, Bleijenberg G, Fennis JF, Galama JM, van der Meer JW Chronic fatigue syndrome: a clinical and laboratory study with a well matched control group. J Intern Med. 1995;237:499–506.

Tobi M, Morag A, Ravid Z, et al Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr virus infection. Lancet. 1982;1:61–4.

Vollmer-Conna U, Wakefield D, Lloyd A, et al Cognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression. Br J Psychiatry. 1997;171:377–81.

Warren G, McKendrick M, Peet M The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999;99:112–6. [PubMed]

(And some more related illnesses of similar nature that monolaurin defeats.)

Baraniuk JN, Clauw DJ, Gaumond E Rhinitis symptoms in chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1998;81:359–65. [PubMed]

Buchwald D, Umali J, Stene M Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia. J Rheumatol. 1996;23:739–42. [PubMed]

Kaslow JE, Rucker L, Onishi R Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501–3. [PubMed]

Hickie I, Lloyd A, Hadzi-Pavlovic D, Parker G, Bird K, Wakefield D Can the chronic fatigue syndrome be defined by distinct clinical features? Psychol Med. 1995;25:925–35. [PubMed]

Lawrie SM, Pelosi AJ Chronic fatigue syndrome in the community. Prevalence and associations. Br J Psychiatry. 1995;166:793–7. [PubMed]

Sharpe M, Hawton K, Seagroatt V, Pasvol G Follow up of patients presenting with fatigue to an infectious diseases clinic. BMJ. 1992;305:147–52. [PubMed] [Free Full text in PMC]

Shor S. Pathogenesis of chronic fatigue syndrome, a multisystem hypotheses. J of Chronic Fatigue SyTirelli V, Pinto A, Marotta G, et al Clinical and immunologic study of 205 patients with chronic fatigue syndrome: a case series from Italy. Arch Intern Med. 1993;153:116–7, 120. [PubMed]

Wessely S, Powell R Fatigue syndromes: a comparison of chronic “postviral” fatigue with neuromuscular and affective disorders. J Neurol Neurosurg Psychiatry. 1989;52:940–8. [PubMed]

Wessely S, Hotopf M, Sharpe M 1998. Chronic fatigue and its syndromes. Oxford; New York: Oxford University Press.

White KP, Speechley M, Harth M, Ostbye. T Co-existence of chronic fatigue syndrome with fibromyalgia syndrome in the general population: a controlled study. Scand J Rheumatol. 2000;29:44–51. [PubMed]